Derek Jeter, take note! Mark Sanchez made the most of his timeouts by romancing not one, but two women within a few hours at the Moderne Hotel on West 55th Street,sources say.

The handsome New York Jets quarterback, who led his team to a 37-10 rout of the Kansas City Chiefs on Sunday, was spotted with a beautiful brunette checking into the hotel at about 3 a.m. Tuesday.

A witness reports Sanchez’s companion was “a Spanish-looking brunette.” She was seen leaving the Moderne at 8:30 a.m., when a chivalrous Sanchez walked her downstairs.

NYpost source told us,

“He was dead-sober and very polite, said goodbye, and he went right upstairs.”

But just two hours later, after Sanchez ordered room service for himself, a pretty blonde came to the Moderne to join him at about 10:45 a.m. and went up to his room. But the tryst didn’t last long — Sanchez and the woman left the hotel 45 minutes later.

“He called at 11:30 for a car service to Jersey, and they both came down about 15 minutes later and left separately,”

our source told us. The usually dapper Sanchez — who was wearing sweatpants, a hoodie, vest and hat — walked out hurriedly, but politely.

The Post this week revealed how Yankee captain Jeter gives his conquests signed baseb*** as a parting gift, but it is not known if Sanchez’s ladies scored a team memento.

Sanchez, 25, has been linked to a string of beauties since he arrived in the Big Apple two years ago, including actresses Jamie-Lynn Sigler and Hayden Panettiere, who it turned out is dating his pal and teammate Scotty McKnight.

In January, he reportedly wooed a then 17-year-old Connecticut high-school student, Eliza Kruger, after meeting her at Manhattan hot spot Lavo. Staff at the Moderne declined to comment. A rep for Sanchez and the Jets didn’t get back to us.

News like this is not uncommon for a professional athlete.